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以通讯作者在包括Nature Chemical Biology、Nucleic Acids Research、Nature Communications等期刊发表SCI论文150余篇(ResearchGate citations: 5553, h-index: 41)。主编出版6部中英文著作和教材。
代表性著作/教材：
1、 Liu Long, Chen Jian. 《Systems and Synthetic Biotechnology for Production of Nutraceuticals》(Springer-Nature出版社)，2019年, ISBN: 978-981-15-0445-7.
2、 Liu Long, Du Guocheng, Liu Yanfeng. 《Systems and Synthetic Metabolic Engineering》(Elsevier出版社). 2020年. ISBN: 978-0-12-821753-5.
3、 堵国成、刘龙、宋航. 《生物工艺学》.(科学出版社). 2021年. ISBN: 978-7-04-049006-0.
代表性论文：
1、 Yu Wenwen, Jin Ke, Wu Yaokang, Zhang Quanwei, Liu Yanfeng, Li Jianghua, Du Guocheng, Chen Jian, Lv Xueqin, Ledesma-Amaro Rodrigo, Liu Long*. A pathway independent multi-modular ordered control system based on thermosensors and CRISPRi improves bioproduction in Bacillus subtilis. Nucleic Acids Research. 2022. 50: 6587-6600.
2、 Xu Yameng, Wang Xinglong, Zhang Chenyang, Zhou Xuan, Xu Xianhao, Han Luyao, Lv Xueqin, Liu Yanfeng, Liu Song, Li Jianghua, Du Guocheng, Chen Jian, Ledesma-Amaro Rodrigo, Liu Long*. De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts. Nature Communications. 2022. 13: 3040.
3、 Lv Xueqin, Jin Ke, Sun Guoyun, Ledesma-Amaro Rodrigo, Liu Long*. Microscopy imaging of living cells in metabolic engineering. Trends in Biotechnology. 2022. 40: 752-765.
4、 Deng Chen, Wu Yaokang, Lv Xueqin, Li Jianghua, Liu Yanfeng, Du Guocheng, Chen Jian, Liu Long*. Refactoring transcription factors for metabolic engineering. Biotechnology Advances. 2022. 57: 107935.
5、 Lv Xueqin, Hueso-Gil Angeles, Bi Xinyu, Wu Yaokang, Liu Yanfeng, Liu Long*, Ledesma-Amaro Rodrigo*. New synthetic biology tools for metabolic control. Current Opinion in Biotechnology. 2022. 76: 102724.
6、 Ling Meixi, Wu Yaokang, Tian Rongzhen, Liu Yanfeng, Yu Wenwen, Tao Guanjun, Li Jianghua, Du Guocheng*, Ledesma-Amaro Rodrigo, Liu Long*. Combinatorial pathway engineering of Bacillus subtilis for production of structurally defined and homogeneous chitooligosaccharides. Metabolic Engineering. 2022. 70: 55-66.
7、 Qu Lisha, Xiu Xiang, Sun Guoyun, Zhang Chenyang, Yang Haiquan, Liu Yanfeng, Li Jianghua, Du Guocheng, Lv Xueqin, Liu Long*. Engineered yeast for efficient de novo synthesis of 7-dehydrocholesterol. Biotechnology and Bioengineering. 2022. 119: 1278-1289.
8、 Jiang Wei, Villamor David Hernandez, Peng Huadong, Chen Jian, Liu Long, Haritos Victoria, Ledesma-Amaro Rodrigo. Metabolic engineering strategies to enable microbial utilization of C1 feedstocks. Nature Chemical Biology. 2021. 17: 845-855.
9、 Deng Chen, Lv Xueqin, Li Jianghua, Zhang Hongzhi, Liu Yanfeng, Du Guocheng, Ledesma-Amaro Rodrigo, Liu Long*. Synergistic improvement of N-acetylglucosamine production by engineering transcription factors and balancing redox cofactors. Metabolic Engineering. 2021. 67: 330-346.
10、 Xu Xianhao, Li Xueliang, Liu Yanfeng, Zhu Yonglian, Li Jianghua, Du Guocheng, Chen Jian, Ledesma- Amaro Rodrigo, Liu Long*. Pyruvate-responsive genetic circuits for dynamic control of central metabolism. Nature Chemical Biology. 2020. 16: 1261-1268.
11、 Tian Rongzhen, Liu Yanfeng, Cao Yanting, Zhang Zhongjie, Li Jianghua, Liu Long, Du Guocheng, Chen Jian*. Titrating bacterial growth and chemical biosynthesis for efficient N-acetylglucosamine and N-acetylneuraminic acid bioproduction. Nature Communications. 2020. 11: 5078.
12、 Wu Yaokang, Chen Taichi, Liu Yanfeng, Tian Rongzhen, Lv Xueqin, Li Jianghua, Du Guocheng, Chen Jian, Ledesma-Amaro Rodrigo, Liu Long*. Design of a programmable biosensor-CRISPRi genetic circuits for dynamic and autonomous dual-control of metabolic flux in B. subtilis. Nucleic Acids Research. 2020. 48: 996-1009.
13、 Xu Xianhao, Liu Yanfeng, Du Guocheng, Ledesma-Amaro Rodrigo, Liu Long*. Microbial chassis development for natural products biosynthesis. Trends in Biotechnology. 2020. 38: 779-796.
14、 Lv Xueqin, Zhang Cheng, Cui Shixiu, Xu Xianhao, Wang Lingling, Li Jianghua, Du Guocheng, Chen Jian, Ledesma-Amaro Rodrigo, Liu Long*. Assembly of pathway enzymes by rationally engineering functional membrane microdomains for improved N-acetylglucosamine synthesis in Bacillus subtilis. Metabolic Engineering. 2020. 61: 96-105.
15、 Lv Xueqin, Wu Yaokang, Tian Rongzhen, Gu Yang, Liu Yanfeng, Li Jianghua, Du Guocheng, Ledesma-Amaro Rodrigo, Liu Long*. Synthetic metabolic channel by functional membrane microdomains for compartmentalized flux control. Metabolic Engineering. 2020. 59: 106-118.
16、 Deng Jieying, Chen Chunmei, Gu Yang, Lv Xueqin, Liu Yanfeng, Li Jianghua, Ledesma-Amaro Rodrigo, Du
Guocheng, Liu Long*. Creating an in vivo bifunctional gene expression circuit through an aptamer-based regulatory mechanism for dynamic metabolic engineering in Bacillus subtilis. Metabolic Engineering. 2019. 55: 179-190.
17、 Gu Yang, Liu Yanfeng, Li Jianghua, Du Guocheng, Ledesma-Amaro Rodrigo, Liu Long*. Synthetic redesign of central carbon and redox metabolism for high yield production of N-acetylglucosamine in Bacillus subtilis. Metabolic Engineering. 2019. 51: 59-69.
18、 Wu Yaokang, Chen Taichi, Liu Yenfeng, Lv Xueqin, Li Jianghua, Du Guocheng, Ledesma-Amaro Rodrigo, Liu Long*. CRISPRi allows optimal temporal control of N-acetylglucosamine bioproduction by a dynamic coordination of glucose and xylose metabolism in Bacillus subtilis. Metabolic Engineering. 2018. 49: 232-241.
19、 Gu Yang, Xu Xianhao, Wu Yaokang, Niu Tengfei, Liu Yanfeng, Li Jianghua, Du Guocheng, Liu Long*. Advances and prospects of Bacillus subtilis cellular factories: from rational design to industrial applications. Metabolic Engineering. 2018. 50: 109-121.
20、 Liu Yanfeng, Link Hannes, Liu Long*, Du Guocheng, Chen Jian*, Sauer Uwe. A novel dynamic pathway analysis approach reveals a limiting futile cycle in N-acetylglucosamine overproducing Bacillus subtilis. Nature Communications. 2016. 7:11933 |
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获得中国授权发明专利50项，美国授权发明专利15项。部分美国授权发明专利如下：
1. Liu Long, Lv Xueqin, Du Guocheng, Li Jianghua, Chen Jian. Recombinant Bacillus subtills and use thereof. 授权专利号：US 11,136,545 B2
2. Liu Long, Chen Jian, Du Guocheng, Lv Xueqin, Li Jianghua, Jiang Zhu, Lu Wei, Zhang Hongzhi, Lu Jianxing, Liu Changfeng. Construction and application of engineering bacteria capable of secreting and expressing diacetylchitobiose deacetylase. 授权专利号：US 10,934,552 B2
3. Liu Long, Chen Jian, Du Guocheng, Li Jianghua, Wu Yaokang, Chen Taichi. Method for producing N-acetylglucosamine by co-utilizing glucose and xylose based on CRISPRi. 授权专利号：US 10,633,658 B2
4. Liu Long, Chen Jian, Du Guocheng, Yin Xian, Li Jianghua. Transgenic strain containing an isolated promoter. 授权专利号：US 10,669,550 B2
5. Liu Long, Gu Yang, Deng Jieying, Chen Jian, Du Guocheng, Li Jianghua. Recombinant strain of Bacillus subtilis. 授权专利号：US 10,669,532 B2
6. Liu Long, Li Jianghua, Niu Tengfei, Chen Jian, Du Guocheng. Recombinant Bacillus subtilis for increasing production of acetylglucosamine and construction method thereof. 授权专利号：US 10,465,198 B2
7. Liu Long, Chen Jian, Du Guocheng, Li Jianghua, Niu Tengfei. Recombinant Bacillus subtilis for producing acetylglucosamine and construction method thereof. 授权专利号：US 10,093,936 B2
8. Liu Long, Chen Jian, Du Guocheng, Yin Xian, Li Jianghua. Method of gene expression regulation. 授权专利号：US 2018/0171344 A1
9. Liu Long, Chen Jian, Du Guocheng, Li Jianghua, Liu Yanfeng, Hannes Link, Uwe Sauer. Method for enhancing N-acetylglucosamine production through glck knockout of Bacillus subtilis. 授权专利号：US 9,914,949 B2
10. Liu Long, Chen Jian, Du Guocheng, Yin Xian, Li Jianghua. Promoter and use thereof. 授权专利号：US 9,926,569 B2. |
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